 |
|
|
| |
|
Publications
|
Sun C, Hunt DK, Clark RB, Lofland D, O'Brien WJ, Plamondon L, Xiao XY.
Synthesis and Antibacterial Activity of Pentacyclines: A Novel Class of Tetracycline Analogs.
J.Med.Chem. 2011 Jun 9; 54(11): 3704-31. Epub 2011 May 10.
|
|
|
Clark RB, He M, Fyfe C, Lofland D, O'Brien WJ, Plamondon L, Sutcliffe JA, Xiao XY.
8-Azatetracyclines: Synthesis and Evaluation of a Novel Class of Tetracycline Antibacterial Agents.
J.Med.Chem. 2011 Mar 10; 54(5): 1511-28. Epub 2100 Feb 8.
|
|
|
Sun C, Wang Q, Brubaker JD, Wright PM, Lerner CD, Noson K, Charest M, Siegel DR, Wang YM, Myers AG.
A robust Platform for the synthesis of new tetracycline antibiotics.
J.AM.CHEM. SOC. 2008;130:17913-17927.
|
|
|
Charest MG, Lerner CD, Brubaker JD, Siegel DR, Myers AG.
A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics.
Science. 2005 Apr 15;308(5720):395-8.
|
|
Posters/Presentations
Poster Presented at the 51st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 17-20, 2011
|
X. Xiao, Y. Deng, C. Sun, C. Fyfe, W. O'Brien, T. Grossman, J. Sutcliffe.
Antibacterial Activity of Novel 7, 9-Disubstituted Tetracycline Analogs, Poster F1-1855.
|
|
|
R. B. Clark, M. He, C. Sun, Y. Deng, C. Chen, X. Xiao, W. O'Brien, C. Fyfe, T. Grossman, and J. Sutcliffe.
Antibacterial Activity of Novel 8-Aminomethyl Substituted Tetracyclines, Poster F-1856.
|
|
|
X. Xiao, C. Fyfe, W. O'Brien, T. Grossman, J. Sutcliffe.
Synthesis and Antibacterial Activity of Polycyclines: A Novel Class of Tetracycline Analogs, Poster F-1857.
|
|
|
J. Sutcliffe, T. Grossman, M. Ronn, X. Xiao, A. Leighton.
TP-434 Has Potential to Treat Complicated Urinary Tract Infections (cUTI), Poster F-1858.
|
|
|
C. Fyfe, T. Farrell, J. Sutcliffe, and T. Grossman.
Development and Characterization of a Coupled Transcription/Translation (TNT) Assay from Pseudomonas aeruginosa, Poster F2-158.
|
|
|
W. O'Brien, J. Sutcliffe, and T. Grossman.
TP-434 is Synergistic In Vitro with Amphotericin B, Fluconazole and Caspofungin Against Candida spp., Poster F-1380.
|
|
Poster Presented at the 21st ECCMID/27th ICC, May 7-10, 2011
|
C. Pillar, D. Sahm, T. Grossman, J. Sutcliffe.
The Effects of Varying Susceptibility Test Parameters on TP-434 in vitro.
|
|
|
T. Grossman, W. O'Brien, C. Fyfe, C. Sun, W. Zhang, and J. Sutcliffe.
In Vitro Activity of TP-2758 against Panels of Recent Bacterial Clinical Isolates.
|
|
|
C. Fyfe, T. Grossman, W. O'Brien, C. Achorn, J. Sutcliffe.
The Novel Broad-Spectrum Fluorocycline TP-434 is Active Against MDR Gram-Negative Pathogens
|
|
Poster Presented at the Chemical and Biological Defense Science and Technology Conference, October 15, 2010
|
T.Grossman, H. Heine III, R.Clark, D. Hunt, C. Sun, X. Xiao, C. Fyfe, W.O. Brien, C. Achorn, J. Sutcliffe.
Novel Fully Synthetic Tetracyclines with Broad Spectrum Activity Against Biothreat Pathogens.
|
|
Posters Presented at the 50th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 12-15, 2010
|
R. Clark, X. Xiao, D. Hunt, M. He, C. Fyfe, W. O'Brien, and L. Plamondon.
Fluorocyclines: A New Class of Broad-Spectrum Tetracyclines with Antibacterial Properties, Poster F1-2155.
|
|
|
T. Grossman, D. Hunt, H. Hein III, J. Sutcliffe.
TP-271, a Novel Oral Fluorocycline for Community-Acquired Respiratory and Biothreat Pathogens, Poster F1-2156.
|
|
|
D. Hunt, X. Xiao, R. Clark, W.O'Brien, C. Fyfe, T. Grossman, J. Sutcliffe, and L. Plamondon.
TP-434 is a Novel Broad-Spectrum Fluorocycline, Poster F1-2157.
|
|
|
J. Sutcliffe, W.O'Brien, C. Achorn, P. Appelbaum, C. Pillar, G. Zurenko.
In Vitro Activity of Fluorocycline TP-434 Against Panels of Recent Bacterial Clinical Isolates, Poster F1-2158.
|
|
|
J. Dubois, M. Dubois, J.F. Martel, T. Grossman, J. Sutcliffe.
In Vitro Activity of Fluorocyclines Against Legionella pneumophila, Poster F1-2159.
|
|
|
A. L. Starosta, C. Fyfe, D. N. Wilson, J. Sutcliffe, T. Grossman.
Target-and Resistance-Based Mechanistic Studies with Fluorocyclines TP-434 and TP-271, Poster F1-2160.
|
|
|
T. Murphy, A. Slee, J. Sutcliffe.
TP-434 is Highly Efficacious in Animal Models of Infection, Poster F1-2161.
|
|
|
D. Christ and J. Sutcliffe.
TP-434 is Metabolically Stable and Has Low Potential for Drug-Drug Interactions, Poster F1-2162.
|
|
|
M. Ronn, N. Dunwoody and J. Sutcliffe.
Pharmacokinetics of TP-434 in Mouse, Rat, Dog, Monkey and Chimpanzee, Poster F1-2163.
|
|
|
W. J. Weiss, M. Pulse, P. Renick and J. Sutcliffe.
Efficacy of Fluorocycline, TP-434 in the Neutropenic Thigh Infection Model is Predicted by AUC/MIC, Poster F1-2164.
|
|
|
C. Seng Yue, J. Sutcliffe, P. Colucci, C.R. Sprenger, M.P. Ducharme.
Population Pharmacokinetic Modeling of TP-434, a Novel Fluorocycline, Following Sngle and Multiple Dose Administration, Poster A1-028.
|
|
Poster Presented at the Society of Toxicology 49th Annual Meeting (SOT), Salt Lake City, UT, March 7-11, 2010
|
C. Sambuco, et al.
An Integrated Approach to Phototoxicity Testing: The In Vivo 3T3 NRU Phototoirritancy Assay and the Albino Hairless Mouse Model With Intracutaneous Administration and a High Dose of Ultraviolet A Radiation
|
|
Posters Presented at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), September 12-15, 2009
|
D. Lofland, W. O'Brien, X. Xiao, D. Hunt, R. Clark, and L. Plamondon.
Oral Antibacterial Activity of a Novel Pentacycline F1-1219.
Presenter (J. Sutcliffe).
|
|
|
D. Lofland, W. O'Brien, X. Xiao, R. Clark, and L. Plamondon.
Synthesis and Antibacterial Activities of Pentacyclines: A Novel Class of Tetracycline Analogs, Poster F1-1516.
|
|
|
D. Lofland, W. O'Brien, X. Xiao, D. Hunt, R. Clark, M. He, and L. Plamondon.
In Vitro and In Vivo Activities of Novel Broad-Sprectrum 8-Aza Tetracyclines, Poster F1-1515
|
|
|
X. Xiao, R. Clark, M. He, D. Lofland, W. O'Brien, and L. Plamondon.
Synthesis and Antibacterial Activities of Aza Tetracyclines: A Novel Class of Tetracycline Analogs, Poster F1-1514
|
|
|
|
|
|
|
